ANTI-ULCER POTENTIAL OF VARIOUS SOLVENT EXTRACTS OF TAGETES ERECTA

Abstract

A Peptic ulcer is the most prevailing problem of the gastrointestinal tract correlated with multiple aetiologies occurs due to interferences of aggressive and cytoprotective factors of the gastric mucosa. Medicinal herbs play an essential role in the treatment of various illnesses by maximizing safety, efficacy and minimizing cost. Tagetes erecta Commonly known as Marigold is an ornamental medicinal herb traditionally used to treat various disease including external ulcers. However, there is no proper scientific data to prove its antiulcer activity. Hence the present research was designed to investigate the antiulcer activity of three different extracts (petroleum ether, Dichloromethane and Ethanol) of Tagetes erecta. Antiulcer activity was evaluated using three different models such as pyloric ligation induced gastric ulcer, aspirin-induced ulcer and alcohol-induced ulcer. All the three extracts of Tagetes erecta showed marked anti-ulcer activity by increasing ulcer protection. The present findings revealed the significant antiulcer activity of Tagetes erecta. Hence it can be utilized in a suitable form as an alternative to available synthetic medicines for treating ulcer.