ROLE OF TINOSPORA CORDIFOLIA (GILOY) IN BONE MAINTENANCE DISORDER (OSTEOPOROSIS) BY DOCKING ANALYTICAL STUDY

Authors

  • Shouvik Kumar nandy Assistant Professor (Pharmacology), Burdwan Institute of Pharmacy, Purba Barddhaman, (W.B), 713103, West Bengal State Council of Technical & Vocational Education and Skill Development. 713103
  • Debajyoti Sarkar Assistant Professor (Pharmacology), Bharat Technology, Howrah, (W.B), 711316, Moulana Abul Kalam Azad University of Technology
  • Rimpa Goswami Assistant Professor (Pharmaceutics), Burdwan Institute of Pharmacy, Purba Barddhaman, (W.B), 713103, West Bengal State Council of Technical & Vocational Education and Skill Development
  • Amrita Sarkar Assistant Professor (Pharmaceutical Chemistry), Burdwan Institute of Pharmacy, Purba Barddhaman, (W.B), 713103, West Bengal State Council of Technical & Vocational Education and Skill Development
  • Shibnath Mukherjee Assistant Professor (Industrial Pharmacy), Burdwan Institute of Pharmacy, Purba Barddhaman, (W.B), 713103, West Bengal State Council of Technical & Vocational Education and Skill Development

Keywords:

T. cordifolia, Guduchi, Osteoporosis, Osteoblast, Osteoclast, RANKL, OPG, BMD, M-CSF.

Abstract

  1. cordifolia commonly known as guduchi is an indigenous plant and has medicinal values for ethnic groups of Himalayan region. It belongs to the family Menispermaceae. It is traditionally valued for rejuvenile drug with immune-modulatory potential, treatment of gout, meha, antidote of snake bite. This review paper provides comprehensive information on the botany, traditional uses, phytochemistry, and pharmacological research on T. cordifolia, based on the scientific literature. It has important role in local and popular medicine, specifically for boosting immune system in humans and helps to improve bone related disorder like, Osteoporosis (Fig 1). More than 30 active constituents are present in this plant that can be extracted by ethanolic extraction process. They are highly active to bind with RANKL/ OPG genes. This in-silico docking study suggest Berberine, Palmatine, cordifolioside A, Tinosporinone, Ecdysterone, Isocolumbin and Tinocordifolin have low binding affinity and they carry significant role in Bone maintenance disorder (Osteoporosis).

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How to Cite

Shouvik Kumar nandy, Debajyoti Sarkar, Rimpa Goswami, Amrita Sarkar, & Shibnath Mukherjee. (2022). ROLE OF TINOSPORA CORDIFOLIA (GILOY) IN BONE MAINTENANCE DISORDER (OSTEOPOROSIS) BY DOCKING ANALYTICAL STUDY. EPRA International Journal of Research and Development (IJRD), 7(4), 1–8. Retrieved from http://www.eprajournals.net/index.php/IJRD/article/view/227

Issue

Vol. 7 No. 4 (2022): EPRA International Journal of Research and Development (IJRD)

Section

Articles