A REVIEW ON FLOATING DRUG DELIVERY SYSTEMS

Abstract

 Oral drug delivery is a convenient and easy method for administering drugs, but it has disadvantages such as inability to determine the site of action, low bioavailability, and potential interactions with the gastric gastrointestinal tract. Gastro-retentive drug delivery systems offer a novel approach, allowing controlled drug release to prolong absorption and transport the medication to its intended location.  This method requires increased gastric residence time, increased bioavailability, reduced drug waste, and increased solubility. It is particularly useful for local action in the stomach, such as treating peptic ulcers or drugs less soluble in basic pH sites. Floating Drug Delivery System (FDDS) is a novel approach targeting the upper GIT of the stomach, enhancing absorption and bioavailability. This system, formulated with a hydrodynamically balanced system (HBS), gradually releases the medication at a regulated pace, allowing it to stay in the stomach and improve the availability of drugs with low stability. This extended duration of gastric residence time (GRT) and improved plasma drug concentration fluctuations are key benefits. HBS systems can release medication gradually in the stomach due to their low bulk density, addressing short gastric residence time issues.