AN IN-VITRO STUDY TO SCREEN DOOSHIVISHARI AGADA FOR ITS BUTRYL CHOLENESTRASE ACTIVITY IN ALZHEIMER’S DISEASE

Abstract

Agadatantra is a specialized branch of Ayurveda which deals with the management of toxicity. The specialized branch has given the novel concept of Dooshivisha (cumulative poison) which is a transformable state of Visha (toxins) which can be attained by any type of poison. Dooshivisha (cumulative poison) is a concept which can be correlated with the etiological factors and pathogenesis of Alzheimer’s disease in modern perspective. For the management of Dooshivisha various treatment procedures have been described, one among them is Dooshivishari. It is herbo-mineral formulation which is explained by Sushruta and Vagbhata. This is indicated in Dooshivisha (cumulative poison) and its complications, insect poisoning and other associated signs and symptoms. Recent understanding of Alzheimer’s disease reveals the role of toxins as a potential etiological factors, where person is exposed to many toxins on daily basis like metals environmental pollutants, excessive use of fertilizers, cigarette smoking, Genetic and immunological factors leads to Alzheimer’s disease1,2,3,4. Many research works are carried out on the chemical constituents of the each ingredients of Dooshivishari Agada which supports Neuro-protective activity. Alzheimer’s disease can be understood under the heading of Dooshivisha5. Alzheimer’s disease is a neurodegenerative disorder that causes miss foldings in Amyloid plaques and cell death in the neurofibrillary tangles. This causes the memory loss that reduce a person’s ability to do activity. Hence it is implicated that Dooshivishari Agada would possess Neuro-protective activity6, hence the present study has been taken.